Dr Rajiv Desai

An Educational Blog

VULNERABLE PLAQUE

Vulnerable Plaque: ____ ____ Prologue: Worldwide more than 17 million people die every year from cardiovascular disease (CVD) with this number projected to increase to over 23 million by 2030. The vast majority of acute ischemic vascular events occur in relation to an underlying atherosclerotic plaque. Atherosclerotic plaque represents the hallmark lesion of atherosclerosis. Plaque rupture is the dominant initiating event, responsible for 60–70% of acute coronary syndromes (ACS), while plaque erosion is responsible for most of the remainder. Irrespective of the mechanism, the consequence is exposure of a thrombogenic substrate to circulating blood. This in turn triggers platelet aggregation and the coagulation cascade which compromises vascular blood flow resulting in downstream end-organ ischemia and infarction. These events occur abruptly and often without warning. Despite major advances in treatment of coronary artery disease patients, a large number of victims of the disease who are apparently healthy die suddenly without prior […]

5 Comments

NIPAH

Nipah: _____ Figure above shows burial of a victim of Nipah virus in Kozhikode, India. _____ Prologue: An outbreak of probable encephalitis hit Siliguri, India in 2001. All hell broke loose when a cardiologist by the name of Dr Ajit Maity and a nurse associated with Medinova Florence Nursing Home fell victim to this disease. It was reported that both had contracted it while treating a patient. A few other doctors, nurses and paramedics were taken severely ill in another hospital. Ten among those infected medics later died. Soon, Siliguri started resembling a ghost town. The roads were deserted, shops shut and schools were closed for a week. There was misinformation circulated based on rumour and gossip. But worst of all was that some doctors secretly fled. Some doctors were apprehended at Jalpaiguri Railway Station and Bagdogra Airports by citizens before they could slip away. Red-faced politicians had flown in […]

22 Comments

ORGAN DONATION & TRANSPLANTATION (ODT)

  Organ Donation & Transplantation (ODT): ____ Jemima Layzell died of a brain aneurysm in 2012 and her organ donations have helped eight people including five children. ____ Prologue: In 1894, the surgeon Otto Lanz (1865–1935) warned his colleagues not to scoff at a treatment “which aims at replacing the organ that has lost its function in the organism”. Today, no one would doubt the seriousness of a surgeon who treats a disease by replacing an organ. However, it was only around 1900 that the idea of organ replacement became self-evident. The introduction of antibiotics, massive vaccinations of the general population to prevent infectious diseases, and organ transplantation may be considered the miracles of twentieth century medicine. Organ transplantation is the best therapy for terminal and irreversible organ failure. Transplantation has given many a new lease on life and, to many more, an extension that would have otherwise been impossible. […]

33 Comments

HUMAN EVOLUTION

HUMAN EVOLUTION: _ Figure below shows conservator Effie Verveniotou and human origins researcher Dr Louise Humphrey examine the oldest nearly complete modern human skeleton ever found in Britain before it goes on display in the gallery. Cheddar Man is a human male fossil found in Gough’s Cave in Cheddar Gorge, Somerset, England. Excavated in 1903, Cheddar Man is Britain’s oldest complete human skeleton. Cheddar Man lived around 10,000 years ago. Analysis of his nuclear DNA indicates that he was a typical member of the western European population at the time, with lactose intolerance, dark skin, blue eyes, and dark curly or wavy hair. ________ Prologue: Recently, minister of state for human resource development of India said that the Darwinian theory of evolution was scientifically wrong and should not be taught in Indian institutions. Many scientists and students signed a petition calling upon him to withdraw his remarks. Three science academies […]

40 Comments

OXYGEN THERAPY

Oxygen (O2) Therapy: _____ While we inhale 21% of oxygen and 0.04% of carbon dioxide, we exhale 17% of oxygen and 4% of carbon dioxide. _____ Prologue: Oxygen (O2) is a vital element in human survival and plays a major role in a diverse range of biological and physiological processes. Oxygen therapy means using an oxygen cylinder or a machine to breathe in air that contains more oxygen than normal. Oxygen is widely available and commonly prescribed by medical and paramedical staff.  In medical practice, it is among the most universally used agents for the treatment of critical illness and part of the routine treatment in acute shock and emergency medicine. Proper application of oxygen therapy and airway management is lifesaving. In the absence of O2 (hypoxia), cellular respiration ceases and irreversible cellular injury and death occur within minutes. Administered correctly it may be lifesaving. However, renaissance physician Paracelsus noted: […]

43 Comments





Designed by @fraz699.